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1,2-Ethanedithiol CAS 540-63-6

Name: 1,2-Ethanedithiol CAS 540-63-6
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1,2-Ethanedithiol (CAS 540-63-6) is a high-purity organosulfur compound featuring two thiol (-SH) groups attached to an ethylene backbone, presented as a clear to pale green liquid.

With a high purity of 99.9% (GC), this versatile chemical serves as a critical building block in organic synthesis, metal coordination chemistry, and pharmaceutical manufacturing.

Engineered for consistency and reliability, our 1,2-Ethanedithiol meets the stringent quality requirements of research laboratories and industrial-scale production facilities worldwide, enabling precise and efficient synthetic processes across diverse applications.

Product Name :
1,2-Ethanedithiol
CAS No. :
540-63-6
Application :
Lenacapavir intermediates

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Description

1,2-Ethanedithiol (CAS 540-63-6) is produced under strict quality control protocols to ensure high purity 99.9% and low impurity levels, making it suitable for sensitive applications such as pharmaceutical API synthesis and advanced material research.

Properties

Product: 1,2-Ethanedithiol

CAS: 540-63-6

Molecular Formula:C₂H₆S₂

Molecular Weight:94.20 g/mol

Appearance:Clear to pale green liquid

Boiling Point:144-146 °C (lit.)

Melting Point:-41 °C (lit.)

Density:1.123 g/mL at 25 °C (lit.)

Solubility： Insoluble in water; miscible with ethanol, ether, acetone, and benzene

Specification

Items	Specifications
Appearance	Colorless clear liquid
Purity	99.9%min

Applications

1,2-Ethanedithiol is a multifunctional reagent with broad utility in organic synthesis, pharmaceutical manufacturing, and material science, leveraging its unique thiol reactivity and bidentate ligand properties. Key applications include:

1. Pharmaceutical API Synthesis (Lenacapavir Production): A critical application of 1,2-Ethanedithiol is as a thioacetal protecting reagent in the synthesis of Lenacapavir (Sunlenca®), a potent HIV-1 capsid inhibitor. During the API manufacturing process, it reacts with active double bonds in key bicyclic pyrazole carboxylic acid intermediates (under catalysis by p-toluenesulfonic acid, p-TsOH, in acetic acid) to form stable thioacetal structures. This protection prevents unwanted side reactions (e.g., addition, polymerization, oxidation) during subsequent high-activity steps such as fluorination (e.g., with HF·py systems). The thioacetal group can be efficiently deprotected via acidic hydrolysis (p-TsOH/MEK-H₂O) later in the synthesis, ensuring the integrity of the target molecular skeleton. This protection-deprotection strategy contributes to high process yields (≥80% for the two-step sequence) and scalability, making it indispensable for large-scale Lenacapavir production.

2. Organic Synthesis & Heterocycle Formation: Widely used to synthesize 1,3-dithiolanes via condensation reactions with aldehydes or ketones, serving as valuable intermediates for the construction of complex organic molecules. It also enables the synthesis of dithiazepan-3-yl-alkanoic acids through cyclocondensation with amino acids and formaldehyde, supporting drug discovery and fine chemical development.

3. Metal Coordination Chemistry: Acts as a bidentate ligand, forming stable chelate complexes with various metal ions (e.g., transition metals). These complexes are utilized in catalysis, material science, and the development of metal-based catalysts for industrial chemical processes.

4. Peptide Synthesis & Deprotection: Serves as an efficient scavenger in solid-phase peptide synthesis (SPPS), facilitating the deprotection of peptide resins by removing reactive byproducts and ensuring the purity of final peptide products.

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1,2-Ethanedithiol CAS 540-63-6 High-Purity 99.9%

CAS 540-63-6 synthesis of Lenacapavir

1,2-Ethanedithiol CAS 540-63-6 Thioacetal protecting reagent

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